Medication Information:
Thioridazine Hydrochloride (generic) - Mellaril (brand)

Manufacturer: Novatis Pharmaceuticals, East Hanover, NJ (Mellaril); Alpharma, Baltimore (generic); Mylan Pharmaceuticals, Morgantown, WV (generic)
Classification: Antipsychotic
Common Usage: Psychotic disorders. severe behavioral problems such as combativeness and/or explosive hyperexcitable behavior in children

Common Major Side Effects: Drowsiness, dry mouth. constipation. dizziness upon standing, changes in ejaculation. decreased ability to urinate in men with benign prostatic hypertrophy, dermatitis, changes in heart rhythm, lack of appetite. weight gain. extrapiramidal symptoms such as rigidity, motor restlessness and tremor. and tardive dyskinesia (abnormal. involuntary movements).

Interactions ,with Other Medications: Use this drug with caution with central nervous system depressants such as alcohol, barbiturates, narcotics or other psychoactive or anticholinergic drugs, because their effect can be increased.

Common Dosages: The usual starting dose is 50-100mg three times a day with a gradual increase, usually weekly, to a maximum of 800mg daily if necessary. Once effective control of symptoms has been achieved, the dosage may be reduced gradually, usually monthly or less often, to determine the minimum maintenance dose. The total daily dosage ranges from 200 mg to 800 mg. divided into two to four doses. Some patients prefer a single daily dose given at bedtime.

For children ages 2 to 12. the dosage ranges from 0.5 mg to a maximum of 3 mg/kg a day. For hospitalized, severely disturbed or psychotic children, 10 to 25 mg two or three times daily is the usual starting dose. Dosage may be increased gradually, usually weekly, until optimum therapeutic effect is obtained or the maximum has been reached.

Identification: Thioridazine hydrochloride tablets are ax available in 10 mg, 15 mg, 25 mg, 50 mg, 100 mg, 150 mg and 200 mg doses. The colors and symbols on the tablets vary by manufacturer. There are also two liquid forms of the drug available in either a concentrate or suspension form, but the concentrate form has an unpleasant taste. Patients prefer the suspensions.

Storage: For tablets, store below 86 degrees in a light and moisture-tight container. For liquids, store below 77 degrees a tight, amber glass bottle. Do not store medication in bathrooms where it is hot and humid.

Edited by Stephen R. Saklad, PharmD

A SERVICE OF…. Psychopharmacology Update
Note: These guidelines are for general information only. For more specific information, consult your physician or pharmacist.