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Medication Information:
Trazodone (generic) - Desyrel
(brand)
Manufacturer: Apothecon, Princeton, NJ
Classification: Antidepressant, hypnotic
Common Usage: Depression, insomnia
Common
Major Side Effects: Dry mouth, dizziness (particularly
after standing), drowsiness, nervousness, fatigue and nausea or
vomiting
Interactions with Other Medications: Trazodone may increase
the impairment in response to alcohol, barbiturates and other
central nervous system depressants. It may increase blood levels of
digoxin (Lanoxin), phenytoin (Dilantin) and other anticonvulsants.
Trazodone may increase bleeding or bruising in patients taking
warfarin (Coumadin). It may interact with monoamine oxidase
inhibitors (MAOIs--Nardil, Parnate).
Common
Dosages: The initial adult dose for depression is 1 50
mg/day in divided doses. The dose may be increased by 50 mg/day
every three to four days. The maximum dose for outpatients usually
should not exceed 400 mg/day in divided doses. In patients, who are
usually severely depressed, may be given up to but not in excess of
600 mg/day in divided doses. It has become a common practice to use
50-100 mg at bedtime for sleep.
Identification: Trazodone is available in 50 mg, 100 mg,
150 mg and 300 mg tablets. The 50 mg tablets are orange and scored,
with "DESYREL" printed on one side and "MJ 775" on the other side.
The 100 mg tablets are white and scored, with "DESYREL" on one side
and "MJ 776" on the other side. 'The 150 mg tablets are orange and
scored in two sections so the pill can be broken into three doses.
It has "MJ 778" on one side and "50"on each of the
scored sections on the other side. The 300 rug tablets are yellow
with two scored sections. It has "MJ 796" on one side and "100" on
the scored sections on the other side.
Storage: Store at room temperature. Protect from
temperatures above 104 degrees. Keep in a tightly closed,
light-resistant container. Do not store in a bathroom or other area
where heat and humidity can cause the medication to deteriorate
more rapidly than normal.
Edited by
StephenR.Saklad,PharmD
A
SERVICE OF…. Psychopharmacology Update
Note: These guidelines are for general information only.
For more specific information, consult your physician or
pharmacist
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