Medication Information:
Acamprosate (Generic) - Campral (Brand)

Classification: Alcoholism abstinence medication.
Common Usage: Acamprosate is indicated for the maintenance of abstinence from alcohol in patients with alcohol dependence. Acamprosate treatment should begin immediately after abstinence is achieved and should be part of a comprehensive management program that includes psychosocial support. The safety and efficacy of acamprosate has not been established in pediatric patients (younger than 18).

Major Side Effects: The most common side effect associated with the use of acamprosate is diarrhea. Nausea, depression and anxiety have also been reported by some patients taking acamprosate. Use of acamprosate does not eliminate or diminish withdrawal symptoms.

Risks for adverse events of a suicidal nature may be increased for alcohol-dependent patients, especially in the context of alcohol relapse. Alcohol dependent patients, including those being treated with acamprosate, should be monitored for the development of symptoms of depression or suicidal thinking.

Patients with severe renal impairment should not be given acamprosate; a reduced dose is recommended for patients with moderate renal impairment.

Patients who are planning to become pregnant, are pregnant or are a nursing mother should discuss treatment with acamprosate with their prescriber.

This is not a complete list of all known or potential adverse effects.  Notify your prescriber or pharmacist of any symptoms that have started since you began taking this medication, changing its dose, or adding or changing other medication or diet.  Take care when performing any task (for example, driving or operating machinery) that requires your attention until you have experience with this drug and are confident you can perform the task safely.

Interactions with Other Medications: No known adverse drug interactions affecting dosage have been identified for acamprosate. Ingestion of alcohol while taking acamprosate does not lead to any adverse reactions.

This is not a complete list of all known or potential drug interactions.  To help prevent problems, always make sure your pharmacist and all prescribers know all the medications you are taking.  This includes over-the-counter drugs and any dietary or herbal supplements or medications.

Common Dosages:  The recommended dose of acamprosate is 666 mg three times a day (each dose taken as two 333-mg tablets). A lower dose may be effective in some patients. Treatment with acamprosate should be initiated immediately after the patients has achieved abstinence and should be maintained if the patient relapses.

For patients with renal impairment, the dose should be adjusted to 333 mg three times a day. This dose adjustment may be necessary for elderly patients if they have renal impairment.

Identification: Acamprosate tablets are available in 333 mg strength only.  Tablets are enteric-coated, white, and round with 333 imprinted on one side.

Storage: Store this medication at normal room temperature (59° F to 86° F) in a tightly closed, light- and moisture-resistant container.  If you have difficulty opening child-resistant containers, your pharmacist can provide a container that is easier to open.  Keep the medication out of direct sunlight and avoid storing it in a warm or humid area - such as the bathroom or kitchen - to prevent deterioration. 

To prevent accidental poisoning, keep all medications out of the reach of children.  Do not take an expired medication.  Do not transfer medication from one container to another.  Carefully discard discontinued medication where children cannot find it.

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Note: These guidelines are for general information only. For more specific information, consult your physician or pharmacist.